Endocrine Abstracts

Introduction: Long-term glucocorticoid replacement therapy in patients with Addison disease has been linked to an increased cardiovascular risk and consequent mortality. Our objective was to determine the frequency of dyslipidemia in patients with Addison disease and its potential predictive factors.Patients and methods: This was a cross-sectional study, performed in the department of endocrinology in Hedi Chaker hospital –Sfax –Tunisia. Fifty ...

Introduction: Inadequate glucocorticoid replacement therapy in Addison disease leads to an increased risk of both cardiovascular disease and metabolic syndrome. The metabolic effects of long-life corticosteroid exposure are due to physiological mechanisms that are associated with carbohydrate metabolism disorder, dyslipidemia and insulin resistance. In this study, we aimed to determine the prevalence and predictive factors of metabolic syndrome in patients with Addison disease...

Introduction: Conventional glucocorticoid replacement therapy has been suggested to increase morbidity in patients with Addison disease and fail to restore their quality of life (QOL). The aim of our study was to assess QOL in patients with Addison disease and to identify factors that determine their QOL.Patients and methods: This cross-sectional study was carried out at the department of Endocrinology in HediChaker hospital-Sfax –Tunisia, from Marc...

Introduction: Patients with Addison disease require lifelong glucocorticoid replacement treatment and it is recommended that glucocortiocoid therapy should be monitored in these patients to avoid over replacement and minimize long-term consequences of bone loss. The present study was carried out with the aim of evaluating bone turnover markers in patients with Addison disease.Patients and methods: A cross sectional study including 50 patients who are fol...

Introduction: Because of a long-term glucocorticoid replacement over many years, patients with Addison disease may have an increased occurrence of osteoporosis. Furthermore, the prevalence of osteoporosis in patients with Addison disease may also be increased because of premature menopause associated autoimmune endocrinopathies and hypovitaminosis D.The objective of this study is to assess the incidence and risk factors for osteoporosis among patients with Addison disease....

Introduction: Even at physiological doses, glucocorticoid replacement therapy may lead to deleterious outcomes on bone mineral density (BMD).The aim of our study was to investigate the BMD in Tunisian patients with Addison disease and to identify the risk factors associated with its decline.Patients and methods: The study included 50 patients diagnosed with primary adrenal disease (Addison disease). BMD was assessed by the dual -energy -X-ray absopitomet...

Introduction: Obesity, through its complications, influences the functional and vital prognosis. The search for these complications constitutes a major axis of the management of the obese patient, independently of the weight loss. The objective of this work is to focus on the different complications of obesity and to identify, through a comparative study between two groups of obese patients, complicated versus uncomplicated, the different predictive factors of the occurrence o...

Introduction: Addison disease (AD) is associated with high risk of decreased bone mineral density (BMD) and osteoporosis. Causes are complex, including lifelong glucocorticoid replacement therapy. Several studies have pointed a significant relationship between glucocorticoid dose and low BMD in patients with AD. The aim of our study is to assess the impact of glucocorticoid replacement dose on BMD among Tunisian patients with AD.Patients and Methods: We ...

Introduction: Inappropriate glucocorticoid replacement therapy results in higher mortality rates in patients with Addison disease (AD), predominantly due to higher prevalence of cardiovascular diseases, disturbed glycometabolic state and altered anthropometric parameters. The aim of this study was to assess the impact of life-long corticosteroid exposure on anthropometric parameters in patients with AD.Patients and Methods: This Tunisian cross-sectional ...

Introduction: Glucocorticoid replacement therapy may result in long-term morbidities, including cardiovascular diseases which can increase cardiovascular risk. The study was aimed to assess the impact of life-long glucocorticoid replacement therapy on cardiovascular parameters in patients with Addison disease (AD).Patients and Methods: This cross-sectional study was conducted assess cardiovascular events in patients followed for AD for at least 5 years, ...